Author’s response to reviews Title: Ramosetron for the treatment of irritable bowel syndrome with diarrhea: a systematic review and meta-analysis of randomized controlled trials Authors:

Thank you very much for your kind consideration of acceptance of our manuscript entitled “Ramosetron for the treatment of irritable bowel syndrome with diarrhea: a systematic review and meta-analysis of randomized controlled trials” (manuscript No. BMGE-D-16-00400R1) in BMC Gastroenterology. We appreciate very much the comments from the academic editor and reviewers. Those comments are all valuable and very helpful for improving our paper. Following your suggestions, we have removed the response to reviewers from the file inventory, and uploaded our manuscript and as a single, final, clean version. Figures are also uploaded as separate files as clean versions.